PPISR Weekly Seminars: 2016

Scientific seminars are held almost throughout the year, every week, presented by our faculty members, visitors and PhD students.

  1. The advantages and disadvantages of being Polyploid
    Dr. Ananda K., PPISR
    Sep 29, 2016.
  2. Energy and its impact to Petrochemical Technology
    Dr. ZhongYi, Manager, GTC Technology - USA
    Sep 19, 2016.
  3. Therapeutic Targeting of Oncogenic Molecules in Breast and Other Cancers: Nanoparticle based Approach
    Dr. Gopal Kundu, Scientist-G from National Centre for Cell Science (NCCS) Pune
    August 26th, 2016.
  4. Microwave assisted synthesis of organic and inorganic chemicals
    Dr. G. Shanbhag, Asst. Professor, Material Science Division, PPISR
    July 01, 2016
  5. Current progress towards creation of synthetic self-assembling protein scaffolds.
    Dr. Udupi A. Ramagopal, Biological Science Dept, PPISR
    June 24, 2016
  6. Introduction to Dendrimers: Highly Branched Polymers and their Applications
    Dr. Sanjeev P. Maradur. Materials Science Division, PPISR
    June 17, 2016
  7. Plant resistance to Phytopathogenic Nematodes
    Dr. Pramod Kandoth, Bond Life Sciences Center, University of Missouri, USA
    May 27, 2016.
  8. Soft Crystalline Porous Frameworks: Design to Applications
    Dr. Suresh B. Kalidindi, Asst. Professor, Materials Science Division, PPISR.
    May 19, 2016.
  9. Magnetoelectric Materials: An Opportunity for Design of Voltage Controlled Devices?
    Dr Nalini Sundram, Materials Sciences Division
    Apr 22, 2016.
  10. Uncertainty and contextuality: Aspects of quantum strangeness
    Dr R. Srikanth, Theoretical Sciences Division
    Feb 12, 2016.
  11. Diabetes Medication and Mechanism of action
    Dr. Ananda K, Biological Sciences Division
    Jan 29, 2016.
  12. 2015 Nobel Prize in Chemistry: Mechanistic Studies of DNA Repair
    Dr. Raghurama P Hegde, Biological Sciences Division
    Jan 13, 2016.
  13. Relaxor Ferroelectrics: A Unique Class of Smart Materials
    Dr. Sowmya Palimar, Materials Sciences Division
    Dec 30, 2015.

The advantages and disadvantages of being Polyploid

Dr Ananda K.

Abstract: Polyploidy is the heritable condition of possessing more than two complete sets of chromosomes. Polyploids are common among plants, as well as among certain groups of fish, amphibians and recently reported in fungi also. Polyploids arise when a rare mitotic or meiotic catastrophe, such as nondisjunction, causes the formation of gametes that have a complete set of duplicate chromosomes. Diploid gametes are frequently formed in this way. A diploid gamete may fuse with a haploid gamete or with a diploid gamete to form polyploids of different types. Many types of polyploids are found in nature, including tetraploids (four sets of chromosomes), hexaploids (six sets of chromosomes), and other chromosome-pair multiples. In this talk we will discuss the mechanisms underlying polyploidy, and both the advantages and disadvantages of having multiple sets of chromosomes.

Microwave assisted synthesis of organic and inorganic chemicals

Dr. G. Shanbhag

Abstract: In the present era, the prime goal for a synthetic chemist is to actively engage in the development of efficient and environmentally benign synthetic protocols in response to the increasing pressure to produce the large number of substances required by society in an environmentally benign fashion. Various stringent regulations and stipulations that are placed on the chemical industries, especially in the area of waste management, have inspired the scientists to explore environmentally benign methods to carry out the reactions in an expeditious manner with minimized waste generation. There are 4 important such routes; Light induced-photochemistry, Microwave-assisted irradiation, Sonochemistry—ultrasonic irradiation, Mechanochemical mixing. Among them, microwave synthesis has gained a lot of importance of late due to shorter synthesis time for organic/ inorganic materials and uniform nanosized synthesis of inorganic materials. This talk will give the overview of these methods with some of case studies.

Current progress towards creation of synthetic self-assembling protein scaffolds.

Dr. Udupi A. Ramagopal

Abstract: Nature has all the tools and tricks to create repertoire of nano- and micro-structures through the spontaneous self-assembly of highly complicated proteins. Biological molecules that can self-assemble in to a supramolecular structure in an organized way and are genetically tunable, allow us to create biomaterials with a repertoire of structural and functional properties. Although, we are still in the process of understanding the mechanism of protein folding and protein-protein interactions, information on protein structures and their assemblies derived from various techniques is beginning to reveal some of the strategies used by nature. Hence, devising strategies to create biomolecular assemblies is still in the early stages. In this talk, we will be discussing the recent progress in the rational design of nano- and micro-sized architectures utilizing protein scaffolds.

Introduction to Dendrimers: Highly Branched Polymers and their Applications

Dr Sanjeev Maradur

Abstract: Dendrimers are a class of highly branched, multivalent and monodisperse polymers, which have received continuous interest in recent years because of the global demand for new nanomolecules that are useful in advanced technology and medicine. While dendrimers are advantageous for many highly specialized applications, but the high polyvalency of higher-generation dendrimers requires, well-controlled, tailored regioselective chemical engineering. The structural evolution of dendrimers - from simple, monofunctional molecules to the more complex, multifunctional compounds - is inextricably associated with a continuous improvement in traditional synthetic strategies, as well as the development of new synthetic tools. In this seminar, a general introduction to the subject, synthetic stratergies and few applications will be discussed.

Soft Crystalline Porous Frameworks: Design to Applications

Dr. Suresh B. Kalidindi

Abstract: Crystalline materials maximise understanding of the link between atomic-scale structure and function and facilitates the explanation of macroscopic events on the basis of interactions occurring at the molecular level. Among various classes of porous crystalline materials metalorganic frameworks (MOFs) and covalent organic frameworks (COFs) are in lime light in recent times because of their potential applications in various fields ranging from biology to catalysis. As their names suggest, MOFs are built from the connectivity of organic linker and metal ions/metal clusters, and COFs only from the organic building units. The property that makes these classes of materials distinctly different from others is their "supertunability" i.e., the ability to modulate their properties by modifying the building blocks while maintaining the basic topology. In addition, these materials have the largest reported crystalline pores and surface areas which makes them exciting platforms to explore host-guest chemistry. In this presentation, the details of synthesis and characterization techniques, followed by pore surface guided host-guest chemistry of MOFs and COFs will be discussed. The potential applications of these classes of materials in the areas of gas storage, gas separation, and catalysis will also be presented

Magnetoelectric Materials: An Opportunity for Design of Voltage Controlled Devices?

Dr Nalini Sundram

Abstract: In recent years much research is focussed on the magnetoelectric effect exhibited by certain materials, where control of electric polarization can be achieved by a magnetic field and magnetization by electric field. This opens up many new applications for devices that can be controlled by voltage. Some examples are magnetic/ferroelectric data storage, magnetocapacitive devices, magnetic sensors and non-volatile memories. Many of these materials have structures that can be tuned by substitution to obtain the desired application. In such materials we could visualize that the electric fields can not only reorient the polarization but also control magnetization at the same time. These properties are interesting for electricfield control of magnetism which is the right route to more energy efficient devices. The physical principles and the state of the art of these concepts will be discussed from both the fundamental materials point of view as well as from the perspective of their application in voltage controlled devices. These materials could potentially be used for information storage and memory applications as they allow the possibility of switching the magnetization with electric field, thus removing the large electric currents required.

Uncertainty and contextuality: Aspects of quantum strangeness

Dr R. Srikanth

Abstract: Suppose we have three boxes A, B and C, in each of which a gem may be present or not. For some fixed preparation P of the three boxes, suppose that upon opening any two boxes, we find that precisely one of the two opened boxes contains a gem. There is no classical preparation P of priorly filling the gems in the boxes that can satisfy this requirement. A theory that allows a magical preparation P where such anti-correlations occur would be called contextual. Quantum mechanics is such a theory (with a caveat that we must consider a "noisy" version of the above experiment). For the noiseless case, we sketch a 5-box version of the above illustration (where any pair of neighboring boxes must be anti-correlated), where this high degree of anti-correlation been experimentally verified, thereby giving evidence of this aspect of the strangeness of quantum theory. In this 5-box version, for a fixed preparation P for a set of boxes A, B, C, D and E, suppose finding the gem in A entails that a subsequent measurement of C will neither find nor not find the gem with certainty. Then boxes (or more abstractly, properties) A and C have an uncertainty relation. Although uncertainty and contextuality are logically independent, they are intertwined in quantum theory in a specific way.

Diabetes Medication and Mechanism of action

Dr Ananda

Abstract.Diabetes is a metabolic disease which creates abnormal level of glucose in the blood. Excess of glucose in the blood is processed with the help of insulin hormones secreted by the pancreas. Diabetes disrupts this process, so the glucose is not properly converted into energy. The onset of diabetes indicated by several symptoms which are unusual for a healthy human. There are methods to detect diabetes and people with diabetes need medications to improve sugar absorption or manage insulin levels in the body. Each drug has its own type of mechanism of action. The talk will cover causes, health complications and various medications used for treating diabetes will be discussed with some of their mechanism of action. Finally, some tips for preventing diabetes will be given.

2015 Nobel Prize in Chemistry: Mechanistic Studies of DNA Repair

Dr Raghurama Hegde

Abstract: An organism's genetic material, the genome, encodes the information needed to create a complete organism as well as to sustain it. DNA replication machinery, responsible for making copies of the genomes during cell division, though highly efficient, can make some occasional mistakes. In addition to this, internal chemical processes and external factors like radiation and chemicals can damage DNA. Accumulation of these damages can lead to serious diseases. The cell has developed various DNA repair mechanisms to counteract these damages and maintain the integrity of the genome. Recognizing the importance of understanding the processes of DNA repair the 2015 Nobel Prize in Chemistry was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for their "Mechanistic studies of DNA repair". Today, we understand the molecular mechanisms of DNA repair pathways due to the pioneering work of these three scientists and countless other peers. In this talk I will provide an overview of their work on the mechanisms of DNA repair that led to the award of the Nobel prize to the above three.

References: Popular information article and advanced information article on the 2015 Nobel Prize in Chemistry on the official website of the Nobel Prize (http://www.nobelprize.org) and references therein.

Relaxor Ferroelectrics: A Unique Class of Smart Materials

Dr Sowmya Palimar

Abstract. Ferroelectric materials belong to the class of dielectric materials (Insulators) offering wide range of useful properties. These materials find application in the areas of non volatile memories, capacitors, sensors, IR detectors, optical switches and so on. Relaxor ferroelectrics are a unique class of ferroelectrics, which show slight deviation from the characteristic properties of ferroelectrics and thus gained significant technological importance. Relaxor Ferroelectrics are generally identified as disordered ferroelectrics, where structural disorderliness is the basic requirement to observe the unique relaxor behavior. In this seminar I will discuss how relaxor ferroelectrics behave differently from normal ferroelectrics, and how its property changes as a function of different parameters and their advantages. The seminar will also give a glimpse of the advances and challenges in research on relaxor ferroelectrics.


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